Exposure of Pharmacy Technicians to Antineoplastic Agents: Reevaluation after Additional Protective Measures
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چکیده
منابع مشابه
Exposure of pharmacy technicians to antineoplastic agents: reevaluation after additional protective measures.
In the past, special guidelines and protective measures have been introduced to protect hospital workers during the handling of antineoplastic agents; nevertheless, it was found that they did not prevent the uptake of these toxic compounds. In response, additional protective measures were introduced, including adaptations of the laminar downflow hood, use of special masks, use of double pairs o...
متن کاملReevaluation of a screening program for antineoplastic agents.
A total of 389 compounds and 40 antibiotics were active in the sequential screening program for antineoplastic agents at Lederle Laboratories during the past 8 years . Many of these compounds were folic acid , alkylating agents , or nicotinamide antagonists (thiad.tazoles) . The distribution of anti neoplastic activity against the 3-tumor screen (Sarcoma 180 , 6C3HED ym, and 72j mammary adenoca...
متن کاملExposure of pharmacy personnel to mutagenic antineoplastic drugs.
The Salmonella reversion test was used to measure the mutagenic activities of urine concentrates from individuals preparing cancer chemotherapy agents for i.v. administration. Longitudinal studies were performed in which the total urine produced in 24-hr periods was collected, starting on a Sunday at 7 p.m. after a duty-free weekend and extending over an 8-day period. There was no detectable in...
متن کاملExposure to Antineoplastic Agents Induces Cytotoxicity in Nurse Lymphocytes: Role of Mitochondrial Damage and Oxidative Stress
Cytotoxicity and mitochondrial parameters were studied in isolated lymphocytes and their mitochondria obtained from occupationally exposed nurses through inhalation exposure to antineoplastic drugs and results were compared to those of unexposed nurses. The group of occupationally exposed nurses consisted of 50 individuals ranging in age from 30 to 35 years. The control group included 50 nurses...
متن کاملExposure to Antineoplastic Agents Induces Cytotoxicity in Nurse Lymphocytes: Role of Mitochondrial Damage and Oxidative Stress
Cytotoxicity and mitochondrial parameters were studied in isolated lymphocytes and their mitochondria obtained from occupationally exposed nurses through inhalation exposure to antineoplastic drugs and results were compared to those of unexposed nurses. The group of occupationally exposed nurses consisted of 50 individuals ranging in age from 30 to 35 years. The control group included 50 nurses...
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ژورنال
عنوان ژورنال: Archives of Environmental Health: An International Journal
سال: 1997
ISSN: 0003-9896
DOI: 10.1080/00039899709602893